An important step in integrated circuit (IC) manufacturing is inspection of the chip surface for defects.In practice, there exists a data imbalance problem associated with IC surface defect images which affects the detection performance of a deep learning-based detection model.In this paper, this data imbalance problem is addressed via generating s
Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic Washing Machine Program Selector serine peptidase associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders.This study seeks to contribute to the future design of a one-bead on
Ubiquitination is a dynamic post-translational modification that regulates virtually all cellular processes by modulating function, localization, interactions and turnover of thousands of substrates.Canonical ubiquitination involves the enzymatic cascade of E1, E2 and E3 enzymes that conjugate ubiquitin to lysine residues giving rise to monomeric u
ObjectiveAbdominoperineal resection (APR) is currently established as a standard treatment regimen for fistula-associated anal adenocarcinoma (FAAA), however, the efficacy of chemoradiotherapy (CRT) remains unclear.The aim of this study is to evaluate the role of Windows - Guides CRT in patients with FAAA treated with APR through single-center expe